Skip to main content

Tofacitinib

Xeljanz

Calculate dosage
Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Immunosuppressant

Routes

PO

Indications

Immune-mediated disease (investigational)

Mechanism of Action

Janus kinase (JAK1/JAK3) inhibitor that blocks signaling of multiple cytokines involved in inflammation and immune response (IL-2, IL-4, IL-6, IL-15, IL-21, IFN).

Side effects & warnings

Investigational in veterinary medicine. Immunosuppression, infection risk. Monitor CBC. May cause GI upset. Potentially useful for immune-mediated diseases unresponsive to standard therapy.

Species with Tofacitinib dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Extrapolated×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Papich Handbook of Veterinary Drugs, 5th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.5–1 mg/kgq12hExtrapolatedPapich Handbook of Veterinary Drugs, 5th Ed
Cat (Domestic)PO0.5–1 mg/kgq12hExtrapolatedPapich Handbook of Veterinary Drugs, 5th Ed

Upgrade for Full Details

Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.

View Plans

More Immunosuppressant drugs

Calculate Dosage for Tofacitinib