ExoticRx · exoticrx.com/drugs/azathioprine
Azathioprine
Imuran
Drug Class
Routes
Indications
Mechanism of Action
Prodrug converted to 6-mercaptopurine, which inhibits purine synthesis. Suppresses T-cell and B-cell proliferation.
Side effects & warnings
TOXIC to cats (severe bone marrow suppression — use only if no alternatives, at very low dose every 48-72h). Monitor CBC regularly. Hepatotoxicity. Pancreatitis. Drug interaction with allopurinol (reduce dose 75%).
Species with Azathioprine dosing data (1 dose rule)
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published primary source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2 mg/kg | q24h initially, then q48h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.