Question 1

What is Tacrolimus Oral used for?

Accepted Answer

Tacrolimus Oral is indicated for: Immune-mediated disease (refractory), transplant.

Question 2

What routes can Tacrolimus Oral be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Tacrolimus Oral dosing data?

Accepted Answer

Tacrolimus Oral dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Tacrolimus Oral a controlled substance?

Accepted Answer

Tacrolimus Oral is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Tacrolimus Oral?

Accepted Answer

Nephrotoxic and diabetogenic. Monitor drug levels, renal function, and blood glucose. Drug interactions with CYP3A4 substrates. Very narrow therapeutic index.

Question 6

What are the side effects of Tacrolimus Oral?

Accepted Answer

Nephrotoxic and diabetogenic. Monitor drug levels, renal function, and blood glucose. Drug interactions with CYP3A4 substrates. Very narrow therapeutic index.

Question 7

How does Tacrolimus Oral work?

Accepted Answer

Binds FKBP12, inhibiting calcineurin and blocking IL-2 transcription. More potent immunosuppressant than cyclosporine (10-100x in vitro).

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.05–0.1 mg/kg	q12h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.05–0.1 mg/kg	q12h	Extrapolated	Plumb's Veterinary Drug Handbook, 9th Ed

Tacrolimus Oral

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Tacrolimus Oral dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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