Question 1

What is Sirolimus used for?

Accepted Answer

Sirolimus is indicated for: Immunosuppression, Immunosuppression (investigational), investigational oncology.

Question 2

What routes can Sirolimus be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Sirolimus dosing data?

Accepted Answer

Sirolimus dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Sirolimus a controlled substance?

Accepted Answer

Sirolimus is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Sirolimus?

Accepted Answer

Immunosuppression increases infection risk. Monitor CBC, liver, renal, and lipids. Drug interactions with CYP3A4 inhibitors. Limited veterinary data outside oncology research.

Question 6

What are the side effects of Sirolimus?

Accepted Answer

Immunosuppression increases infection risk. Monitor CBC, liver, renal, and lipids. Drug interactions with CYP3A4 inhibitors. Limited veterinary data outside oncology research.

Question 7

How does Sirolimus work?

Accepted Answer

Inhibits mammalian target of rapamycin (mTOR), blocking T-cell proliferation driven by IL-2. Also has antiproliferative effects on smooth muscle and tumor cells.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.05–0.1 mg/kg	q24h	Weak	Papich Handbook of Veterinary Drugs, 5th Ed
Cat (Domestic)	PO	0.05–0.1 mg/kg	q24h	Extrapolated	Papich Handbook of Veterinary Drugs, 5th Ed

Sirolimus

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Sirolimus dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

Upgrade for Full Details