Question 1

What is Vincristine used for?

Accepted Answer

Vincristine is indicated for: immune-mediated thrombocytopenia, Lymphoma, Lymphoma (CHOP protocol).

Question 2

What routes can Vincristine be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Vincristine dosing data?

Accepted Answer

Vincristine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Vincristine a controlled substance?

Accepted Answer

Vincristine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Vincristine?

Accepted Answer

VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).

Question 6

What are the side effects of Vincristine?

Accepted Answer

VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).

Question 7

How does Vincristine work?

Accepted Answer

Binds tubulin, inhibiting microtubule assembly and arresting cell division at metaphase. Also stimulates platelet release from megakaryocytes.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.5–0.7 mg/m2	Weekly per protocol	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	0.5 mg/m2	Weekly per protocol	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Vincristine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Vincristine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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