Question 1

What is Capecitabine used for?

Accepted Answer

Capecitabine is indicated for: Carcinomas, Mammary carcinoma adjuvant (investigational), oral fluoropyrimidine (investigational).

Question 2

What routes can Capecitabine be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Capecitabine dosing data?

Accepted Answer

Capecitabine dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Capecitabine a controlled substance?

Accepted Answer

Capecitabine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Capecitabine?

Accepted Answer

CONTRAINDICATED IN CATS — metabolized to 5-FU which is lethal to felines. GI toxicity and hand-foot syndrome in humans. Very limited canine data. Handle with extreme caution around cats.

Question 6

What are the side effects of Capecitabine?

Accepted Answer

CONTRAINDICATED IN CATS — metabolized to 5-FU which is lethal to felines. GI toxicity and hand-foot syndrome in humans. Very limited canine data. Handle with extreme caution around cats.

Question 7

How does Capecitabine work?

Accepted Answer

Oral prodrug of 5-fluorouracil. Converted to 5-FU preferentially in tumor tissue via thymidine phosphorylase, providing tumor-selective activation.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	200–300 mg/kg	200-300mg/m2 PO q12h, 14 days on / 7 days off	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Dog (Domestic)	PO	200–250 mg/kg	200-250mg/m2 PO q12h, 14 days on / 7 days off	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Capecitabine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Capecitabine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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