Question 1

What is Busulfan used for?

Accepted Answer

Busulfan is indicated for: chronic myeloid leukemia, Polycythemia vera.

Question 2

What routes can Busulfan be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Busulfan dosing data?

Accepted Answer

Busulfan dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Busulfan a controlled substance?

Accepted Answer

Busulfan is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Busulfan?

Accepted Answer

Severe myelosuppression — monitor CBC closely. Pulmonary fibrosis with chronic use. Hepatotoxicity (sinusoidal obstruction syndrome). Limited veterinary use for polycythemia vera and CML.

Question 6

What are the side effects of Busulfan?

Accepted Answer

Severe myelosuppression — monitor CBC closely. Pulmonary fibrosis with chronic use. Hepatotoxicity (sinusoidal obstruction syndrome). Limited veterinary use for polycythemia vera and CML.

Question 7

How does Busulfan work?

Accepted Answer

Bifunctional alkylating agent that cross-links DNA strands, interfering with DNA replication and transcription. Preferentially affects granulocyte precursors.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	3–4 mg/kg	PO q24h until target PCV, then maint.	Moderate	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	PO	2–4 mg/kg	PO q24h until remission	Weak	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Busulfan

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Busulfan dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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