Question 1

What is Carboplatin used for?

Accepted Answer

Carboplatin is indicated for: carcinomas, Carcinomas (NOT standard dog dose), melanoma, Osteosarcoma.

Question 2

What routes can Carboplatin be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Carboplatin dosing data?

Accepted Answer

Carboplatin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Carboplatin a controlled substance?

Accepted Answer

Carboplatin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Carboplatin?

Accepted Answer

Less nephrotoxic than cisplatin. Dose-limiting myelosuppression (thrombocytopenia nadir 14-21 days). FATAL IN CATS at standard dog doses. Monitor CBC.

Question 6

What are the side effects of Carboplatin?

Accepted Answer

Less nephrotoxic than cisplatin. Dose-limiting myelosuppression (thrombocytopenia nadir 14-21 days). FATAL IN CATS at standard dog doses. Monitor CBC.

Question 7

How does Carboplatin work?

Accepted Answer

Platinum compound forming DNA intrastrand crosslinks and adducts inhibiting DNA replication and transcription. Cell-cycle non-specific.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	300 mg/m2	q21 days	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	180–240 mg/m2	q21 days	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Carboplatin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Carboplatin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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