Question 1

What is Trabectedin used for?

Accepted Answer

Trabectedin is indicated for: Soft tissue sarcoma (investigational).

Question 2

What routes can Trabectedin be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Trabectedin dosing data?

Accepted Answer

Trabectedin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Trabectedin a controlled substance?

Accepted Answer

Trabectedin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Trabectedin?

Accepted Answer

Hepatotoxicity — monitor liver enzymes. Myelosuppression. Requires central venous access. Very limited veterinary data — investigational for soft tissue sarcomas.

Question 6

What are the side effects of Trabectedin?

Accepted Answer

Hepatotoxicity — monitor liver enzymes. Myelosuppression. Requires central venous access. Very limited veterinary data — investigational for soft tissue sarcomas.

Question 7

How does Trabectedin work?

Accepted Answer

Binds to minor groove of DNA, bending the helix toward the major groove. Interferes with transcription-coupled nucleotide excision repair and modulates tumor microenvironment.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.15–0.3 mg/kg	0.15-0.3mg/m2 IV over 3-24h q21 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	IV	0.1–0.2 mg/kg	0.1-0.2mg/m2 IV over 3h q21 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Trabectedin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Trabectedin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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