Question 1

What is Topotecan used for?

Accepted Answer

Topotecan is indicated for: Lymphoma, Lymphoma (investigational), solid tumors (investigational).

Question 2

What routes can Topotecan be administered by?

Accepted Answer

Available routes: IV, PO.

Question 3

Which species have cited Topotecan dosing data?

Accepted Answer

Topotecan dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Topotecan a controlled substance?

Accepted Answer

Topotecan is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Topotecan?

Accepted Answer

Severe myelosuppression is dose-limiting. Monitor CBC closely. Dose-reduce in renal impairment. Used investigationally for lymphoma and solid tumors in dogs.

Question 6

What are the side effects of Topotecan?

Accepted Answer

Severe myelosuppression is dose-limiting. Monitor CBC closely. Dose-reduce in renal impairment. Used investigationally for lymphoma and solid tumors in dogs.

Question 7

How does Topotecan work?

Accepted Answer

Semi-synthetic camptothecin analogue that inhibits topoisomerase I by stabilizing the enzyme-DNA complex, preventing DNA religation and causing lethal double-strand breaks.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.75–1 mg/kg	IV over 30 min q24h x 5d, q21d cycles	Weak	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	IV	0.5–0.75 mg/kg	0.5-0.75mg/m2 IV q24h x 3-5 days, q21 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Topotecan

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Topotecan dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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