Question 1

What is Toceranib used for?

Accepted Answer

Toceranib is indicated for: Mast cell tumors, various carcinomas.

Question 2

What routes can Toceranib be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Toceranib dosing data?

Accepted Answer

Toceranib dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Toceranib a controlled substance?

Accepted Answer

Toceranib is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Toceranib?

Accepted Answer

FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.

Question 6

What are the side effects of Toceranib?

Accepted Answer

FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.

Question 7

How does Toceranib work?

Accepted Answer

Multi-target TKI inhibiting c-Kit, VEGFR2, PDGFR-beta, and other kinases. Anti-tumor and anti-angiogenic activity.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	2.5–3.25 mg/kg	q48h (every other day)	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	PO	2.5–3.25 mg/kg	q48h (every other day)	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Toceranib

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Toceranib dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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