Question 1

What is Sorafenib used for?

Accepted Answer

Sorafenib is indicated for: Hepatocellular carcinoma (investigational), Thyroid carcinoma (investigational).

Question 2

What routes can Sorafenib be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Sorafenib dosing data?

Accepted Answer

Sorafenib dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Sorafenib a controlled substance?

Accepted Answer

Sorafenib is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Sorafenib?

Accepted Answer

Hand-foot skin reaction not applicable to veterinary patients but GI toxicity and hepatotoxicity occur. Monitor liver enzymes and weight. Used investigationally for hepatocellular carcinoma.

Question 6

What are the side effects of Sorafenib?

Accepted Answer

Hand-foot skin reaction not applicable to veterinary patients but GI toxicity and hepatotoxicity occur. Monitor liver enzymes and weight. Used investigationally for hepatocellular carcinoma.

Question 7

How does Sorafenib work?

Accepted Answer

Inhibits multiple kinases including RAF, VEGFR-2/3, PDGFR-beta, c-KIT, FLT-3, and RET. Anti-proliferative and anti-angiogenic dual mechanism.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	3–5 mg/kg	PO q24h	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Dog (Domestic)	PO	3–5 mg/kg	PO q24h	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Sorafenib

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Sorafenib dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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