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Polyethylene Glycol 3350 (PEG)

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Miscellaneous

Routes

PO

Indications

Chronic constipationConstipation/Megacolon

Mechanism of Action

High molecular weight polymer that is osmotically active but not absorbed, retaining water in the intestinal lumen and softening stool.

Side effects & warnings

Safe for chronic constipation. May cause bloating and flatulence initially. Ensure adequate hydration. Well tolerated in cats and dogs.

Species with Polyethylene Glycol 3350 (PEG) dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published primary sources

  • · Plumb's Veterinary Drug Handbook, 9th Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed; JFMS Constipation Review

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO10–25 mg/kgq12-24hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO10–25 mg/kgq12-24hModeratePlumb's Veterinary Drug Handbook, 9th Ed; JFMS Constipation Review

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