Skip to main content

Buprenorphine Transmucosal (Simbadol)

Simbadol

Calculate dosage
Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Miscellaneous

Routes

SC

Indications

Acute pain management (trauma/injury)Post-operative analgesia (24-hour)

Mechanism of Action

High-concentration buprenorphine providing 24-hour analgesia from a single SC injection. Partial mu-opioid agonist with ceiling effect on respiratory depression.

Side effects & warnings

Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.

Species with Buprenorphine Transmucosal (Simbadol) dosing data (2 dose rules)

Cat (Domestic)

Controlled Substance

Controlled substance

Evidence levels across 2 dose rules

Strong×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published primary sources

  • · Simbadol FDA Product Label
  • · Simbadol FDA Product Label; AAFP Pain Management Guidelines

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Cat (Domestic)SC0.24 mg/kgSingle SC injection q24hStrongSimbadol FDA Product Label; AAFP Pain Management Guidelines
Cat (Domestic)SC0.24 mg/kgq24h SCStrongSimbadol FDA Product Label

Upgrade for Full Details

Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.

View Plans

More Miscellaneous drugs

Calculate Dosage for Buprenorphine Transmucosal (Simbadol)