Question 1

What is Apomorphine used for?

Accepted Answer

Apomorphine is indicated for: Emesis induction (conjunctival route), Emesis induction (in-clinic).

Question 2

What routes can Apomorphine be administered by?

Accepted Answer

Available routes: IV, IM, Conjunctival.

Question 3

Which species have cited Apomorphine dosing data?

Accepted Answer

Apomorphine dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Apomorphine a controlled substance?

Accepted Answer

Apomorphine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Apomorphine?

Accepted Answer

Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse. Do NOT repeat if first dose fails.

Question 6

What are the side effects of Apomorphine?

Accepted Answer

Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse. Do NOT repeat if first dose fails.

Question 7

How does Apomorphine work?

Accepted Answer

Dopamine D2 receptor agonist in the chemoreceptor trigger zone (CRTZ), directly stimulating the vomiting center. Most reliable emetic for dogs.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	Conjunctival	0.25 mg/kg	Single application; flush eye once vomiting begins	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	IV	0.03–0.04 mg/kg	Single IV dose	Strong	Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology

Apomorphine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Apomorphine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by 2 published primary sources

Sample dosing (2 of 2 cited rules)

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