Question 1

What is Pemetrexed used for?

Accepted Answer

Pemetrexed is indicated for: carcinomas (investigational), Mesothelioma, Mesothelioma (investigational).

Question 2

What routes can Pemetrexed be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Pemetrexed dosing data?

Accepted Answer

Pemetrexed dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Pemetrexed a controlled substance?

Accepted Answer

Pemetrexed is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Pemetrexed?

Accepted Answer

Requires folic acid and vitamin B12 supplementation to reduce toxicity. Myelosuppression, skin rash. Renal dosing required. Very limited veterinary data.

Question 6

What are the side effects of Pemetrexed?

Accepted Answer

Requires folic acid and vitamin B12 supplementation to reduce toxicity. Myelosuppression, skin rash. Renal dosing required. Very limited veterinary data.

Question 7

How does Pemetrexed work?

Accepted Answer

Inhibits multiple folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Disrupts both purine and pyrimidine synthesis.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	300–500 mg/kg	300-500mg/m2 IV over 10 min q21 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	IV	200–300 mg/kg	200-300mg/m2 IV q21 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Pemetrexed

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Pemetrexed dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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