Question 1

What is Oxaliplatin used for?

Accepted Answer

Oxaliplatin is indicated for: Colorectal carcinoma, hepatocellular carcinoma, Osteosarcoma adjuvant (investigational).

Question 2

What routes can Oxaliplatin be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Oxaliplatin dosing data?

Accepted Answer

Oxaliplatin dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Oxaliplatin a controlled substance?

Accepted Answer

Oxaliplatin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Oxaliplatin?

Accepted Answer

Peripheral neuropathy (cumulative and acute cold-triggered). Less nephrotoxic and emetogenic than cisplatin. Myelosuppression moderate. Used investigationally for colorectal and hepatic tumors in dogs.

Question 6

What are the side effects of Oxaliplatin?

Accepted Answer

Peripheral neuropathy (cumulative and acute cold-triggered). Less nephrotoxic and emetogenic than cisplatin. Myelosuppression moderate. Used investigationally for colorectal and hepatic tumors in dogs.

Question 7

How does Oxaliplatin work?

Accepted Answer

Third-generation platinum compound that forms inter- and intra-strand DNA cross-links, inhibiting DNA replication and transcription. Different spectrum than cisplatin/carboplatin.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	70 mg/kg	70mg/m2 IV over 2h q14-21 days	Weak	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Dog (Domestic)	IV	70 mg/kg	70mg/m2 IV q14-21 days x 4-6 cycles	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Oxaliplatin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Oxaliplatin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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