Question 1

What is Melphalan used for?

Accepted Answer

Melphalan is indicated for: Multiple myeloma.

Question 2

What routes can Melphalan be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Melphalan dosing data?

Accepted Answer

Melphalan dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Melphalan a controlled substance?

Accepted Answer

Melphalan is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Melphalan?

Accepted Answer

Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.

Question 6

What are the side effects of Melphalan?

Accepted Answer

Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.

Question 7

How does Melphalan work?

Accepted Answer

Bifunctional alkylating agent forming DNA interstrand crosslinks. Cell-cycle non-specific. Phenylalanine derivative of nitrogen mustard.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.05–0.1 mg/kg	q24h x 10 days, then q48h	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.05–0.1 mg/kg	q24h x 10 days then q48h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Melphalan

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Melphalan dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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