ExoticRx · exoticrx.com/drugs/lomustine
CeeNU, Gleostine
Lipophilic nitrosourea that crosses BBB. Alkylates DNA and RNA. Forms DNA interstrand crosslinks and carbamylates proteins.
Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 60–90 mg/m2 | q3-6 weeks | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.