Question 1

What is Hydroxyurea used for?

Accepted Answer

Hydroxyurea is indicated for: CML, meningioma, Myeloproliferative disease, Polycythemia vera.

Question 2

What routes can Hydroxyurea be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Hydroxyurea dosing data?

Accepted Answer

Hydroxyurea dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Hydroxyurea a controlled substance?

Accepted Answer

Hydroxyurea is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Hydroxyurea?

Accepted Answer

Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.

Question 6

What are the side effects of Hydroxyurea?

Accepted Answer

Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.

Question 7

How does Hydroxyurea work?

Accepted Answer

Inhibits ribonucleotide reductase, blocking conversion of ribonucleotides to deoxyribonucleotides. S-phase specific. Reduces elevated cell counts rapidly.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	50–80 mg/kg	50mg/kg PO q24h (some protocols q48h)	Moderate	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	PO	25–50 mg/kg	25mg/kg PO q48-72h	Moderate	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Hydroxyurea

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Hydroxyurea dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

Upgrade for Full Details