Question 1

What is Fluorouracil used for?

Accepted Answer

Fluorouracil is indicated for: actinic keratosis, adenocarcinomas, Carcinomas, Superficial squamous cell carcinoma.

Question 2

What routes can Fluorouracil be administered by?

Accepted Answer

Available routes: IV, Topical.

Question 3

Which species have cited Fluorouracil dosing data?

Accepted Answer

Fluorouracil dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Fluorouracil a controlled substance?

Accepted Answer

Fluorouracil is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Fluorouracil?

Accepted Answer

LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.

Question 6

What are the side effects of Fluorouracil?

Accepted Answer

LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.

Question 7

How does Fluorouracil work?

Accepted Answer

Converted to active metabolites that inhibit thymidylate synthase, blocking DNA synthesis. Also incorporates into RNA, disrupting RNA processing.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	150 mg/kg	150mg/m2 IV weekly	Moderate	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Dog (Domestic)	Topical	0 mg/kg	Apply 5% cream to lesion q12h	Moderate	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Fluorouracil

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Fluorouracil dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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