Question 1

What is Fludarabine used for?

Accepted Answer

Fludarabine is indicated for: CLL (investigational), Low-grade lymphoma, Lymphoid neoplasia (investigational).

Question 2

What routes can Fludarabine be administered by?

Accepted Answer

Available routes: IV, PO.

Question 3

Which species have cited Fludarabine dosing data?

Accepted Answer

Fludarabine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Fludarabine a controlled substance?

Accepted Answer

Fludarabine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Fludarabine?

Accepted Answer

Severe immunosuppression — risk of opportunistic infections. Autoimmune hemolytic anemia. Neurotoxicity at high doses. Limited veterinary data for indolent lymphoid neoplasms.

Question 6

What are the side effects of Fludarabine?

Accepted Answer

Severe immunosuppression — risk of opportunistic infections. Autoimmune hemolytic anemia. Neurotoxicity at high doses. Limited veterinary data for indolent lymphoid neoplasms.

Question 7

How does Fludarabine work?

Accepted Answer

Fluorinated nucleotide analogue of vidarabine. Inhibits DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Induces apoptosis in lymphoid cells.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	15–25 mg/kg	15-25mg/m2 IV over 30 min q24h x 5 days, q28 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)	IV	10–15 mg/kg	10-15mg/m2 IV q24h x 3 days, q28 days	Anecdotal	Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Fludarabine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Fludarabine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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