ExoticRx · exoticrx.com/drugs/etoposide
VePesid, Toposar
Inhibits topoisomerase II forming DNA-drug-enzyme complex causing double-strand DNA breaks. S and G2 phase specific.
Myelosuppression dose-limiting. Hypotension with rapid IV infusion (infuse over 30-60 min). Oral bioavailability variable. Used in some lymphoma rescue protocols.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 60–100 mg/m2 | q21 days | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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