Question 1

What is Doxorubicin used for?

Accepted Answer

Doxorubicin is indicated for: hemangiosarcoma, Lymphoma, mammary carcinoma, osteosarcoma.

Question 2

What routes can Doxorubicin be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Doxorubicin dosing data?

Accepted Answer

Doxorubicin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Doxorubicin a controlled substance?

Accepted Answer

Doxorubicin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Doxorubicin?

Accepted Answer

VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.

Question 6

What are the side effects of Doxorubicin?

Accepted Answer

VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.

Question 7

How does Doxorubicin work?

Accepted Answer

Intercalates DNA, inhibits topoisomerase II, and generates free radicals. Multiple mechanisms of cytotoxicity against rapidly dividing cells.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	30 mg/m2	q21d	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	1 mg/kg	q21d	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Doxorubicin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Doxorubicin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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