ExoticRx · exoticrx.com/drugs/dactinomycin
Cosmegen
Intercalates into DNA between guanine-cytosine base pairs, blocking RNA polymerase and inhibiting transcription. Also causes topoisomerase II-mediated DNA breaks.
Severe vesicant — extravasation causes tissue necrosis. Potent myelosuppression and GI toxicity. Radiosensitizer — avoid concurrent radiation. Very limited veterinary use.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–0.7 mg/kg | 0.5-0.7mg/m2 IV q21 days | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | IV | 0.5–0.7 mg/kg | 0.5-0.7mg/m2 IV q14-21 days | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.