ExoticRx · exoticrx.com/drugs/dacarbazine
DTIC-Dome
Prodrug metabolized to active alkylating metabolite that methylates DNA at O6 and N7 guanine positions. Cell-cycle non-specific.
Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 200 mg/m2 | per DMAC protocol schedule | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.