Question 1

What is Cyclophosphamide used for?

Accepted Answer

Cyclophosphamide is indicated for: immune-mediated diseases, Lymphoma, Lymphoma (CHOP).

Question 2

What routes can Cyclophosphamide be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Cyclophosphamide dosing data?

Accepted Answer

Cyclophosphamide dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Cyclophosphamide a controlled substance?

Accepted Answer

Cyclophosphamide is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Cyclophosphamide?

Accepted Answer

Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.

Question 6

What are the side effects of Cyclophosphamide?

Accepted Answer

Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.

Question 7

How does Cyclophosphamide work?

Accepted Answer

Prodrug activated by hepatic CYP enzymes to form phosphoramide mustard, which alkylates DNA, cross-linking strands and inhibiting replication.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	200–300 mg/m2	q21d or 50 mg/m2 daily x4 days/week	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	200–300 mg/m2	q21d	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Cyclophosphamide

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Cyclophosphamide dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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