Question 1

What is Spironolactone used for?

Accepted Answer

Spironolactone is indicated for: Cardiomyopathy adjunct, CHF adjunct (with furosemide).

Question 2

What routes can Spironolactone be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Spironolactone dosing data?

Accepted Answer

Spironolactone dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Spironolactone a controlled substance?

Accepted Answer

Spironolactone is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Spironolactone?

Accepted Answer

Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.

Question 6

What are the side effects of Spironolactone?

Accepted Answer

Hyperkalemia risk, especially with ACE inhibitors. Monitor electrolytes. Anti-androgenic effects (gynecomastia). Used in CHF as adjunct to furosemide. Give with food.

Question 7

How does Spironolactone work?

Accepted Answer

Competitively blocks aldosterone at mineralocorticoid receptors in the distal nephron. Potassium-sparing diuretic with anti-fibrotic cardiac effects.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	1–2 mg/kg	q12h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	1–2 mg/kg	q12h	Weak	BSAVA Small Animal Formulary, 10th Ed

Spironolactone

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Spironolactone dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by 2 published primary sources

Sample dosing (2 of 2 cited rules)

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