Question 1

What is Amiloride used for?

Accepted Answer

Amiloride is indicated for: Potassium-sparing diuresis, Potassium-sparing diuresis (adjunct).

Question 2

What routes can Amiloride be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Amiloride dosing data?

Accepted Answer

Amiloride dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Amiloride a controlled substance?

Accepted Answer

Amiloride is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Amiloride?

Accepted Answer

Hyperkalemia risk. Weak diuretic alone — usually combined with thiazide or loop diuretic. Avoid in severe renal impairment.

Question 6

What are the side effects of Amiloride?

Accepted Answer

Hyperkalemia risk. Weak diuretic alone — usually combined with thiazide or loop diuretic. Avoid in severe renal impairment.

Question 7

How does Amiloride work?

Accepted Answer

Directly blocks epithelial sodium channels (ENaC) in the distal nephron, reducing sodium reabsorption and decreasing potassium and hydrogen ion secretion.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.1–0.3 mg/kg	q12-24h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.1–0.3 mg/kg	q24h	Extrapolated	Plumb's Veterinary Drug Handbook, 9th Ed

Amiloride

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Amiloride dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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