Question 1

What is Selexipag used for?

Accepted Answer

Selexipag is indicated for: Pulmonary hypertension (add-on therapy), Pulmonary hypertension (investigational).

Question 2

What routes can Selexipag be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Selexipag dosing data?

Accepted Answer

Selexipag dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Selexipag a controlled substance?

Accepted Answer

Selexipag is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Selexipag?

Accepted Answer

Headache, jaw pain, diarrhea, nausea. Slow dose titration required. Investigational for canine pulmonary hypertension as add-on to sildenafil.

Question 6

What are the side effects of Selexipag?

Accepted Answer

Headache, jaw pain, diarrhea, nausea. Slow dose titration required. Investigational for canine pulmonary hypertension as add-on to sildenafil.

Question 7

How does Selexipag work?

Accepted Answer

Selective prostacyclin (IP) receptor agonist that causes pulmonary vasodilation and inhibits vascular smooth muscle proliferation. Active metabolite has high IP selectivity.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	PO	0.01–0.05 mg/kg	q12h	Extrapolated	Veterinary Cardiology Literature Review
Dog (Domestic)	PO	0.01–0.05 mg/kg	q12h	Extrapolated	Veterinary Cardiology Literature Review

Selexipag

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Selexipag dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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