Question 1

What is Ambrisentan used for?

Accepted Answer

Ambrisentan is indicated for: Pulmonary hypertension.

Question 2

What routes can Ambrisentan be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Ambrisentan dosing data?

Accepted Answer

Ambrisentan dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Ambrisentan a controlled substance?

Accepted Answer

Ambrisentan is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Ambrisentan?

Accepted Answer

Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.

Question 6

What are the side effects of Ambrisentan?

Accepted Answer

Hepatotoxicity risk — monitor liver enzymes. Peripheral edema. Teratogenic. Used for pulmonary hypertension in dogs when sildenafil alone is insufficient.

Question 7

How does Ambrisentan work?

Accepted Answer

Selective endothelin type A (ETA) receptor antagonist that blocks endothelin-1 mediated vasoconstriction and smooth muscle proliferation in pulmonary vasculature.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.25–0.5 mg/kg	q24h	Weak	JVIM 2019; Veterinary Cardiology Literature
Cat (Domestic)	PO	0.25–0.5 mg/kg	q24h	Extrapolated	JVIM 2019; Veterinary Cardiology Literature

Ambrisentan

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Ambrisentan dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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