Question 1

What is Riociguat used for?

Accepted Answer

Riociguat is indicated for: Pulmonary hypertension (alternative to sildenafil), Pulmonary hypertension (investigational).

Question 2

What routes can Riociguat be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Riociguat dosing data?

Accepted Answer

Riociguat dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Riociguat a controlled substance?

Accepted Answer

Riociguat is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Riociguat?

Accepted Answer

Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.

Question 6

What are the side effects of Riociguat?

Accepted Answer

Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.

Question 7

How does Riociguat work?

Accepted Answer

Stimulates soluble guanylate cyclase (sGC) directly and sensitizes it to endogenous NO, increasing cGMP production and causing pulmonary vasodilation.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.5–2 mg/kg	q8h	Weak	Veterinary Cardiology Literature Review
Cat (Domestic)	PO	0.5–1.5 mg/kg	q8h	Extrapolated	Veterinary Cardiology Literature Review

Riociguat

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Riociguat dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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