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Propentofylline

Vivitonin, Karsivan

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Respiratory

Routes

PO

Indications

Cognitive dysfunction (off-label)Cognitive dysfunction syndromelethargy in geriatric dogs

Mechanism of Action

Inhibits adenosine reuptake and phosphodiesterase, improving microcirculation and red blood cell deformability. Neuroprotective via adenosine receptor modulation.

Side effects & warnings

Licensed in some countries for canine cognitive dysfunction and lethargy/dullness in old dogs. Give on empty stomach. GI upset rare.

Species with Propentofylline dosing data (2 dose rules)

Evidence levels across 2 dose rules

Moderate×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · BSAVA Small Animal Formulary, 10th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO3–5 mg/kgq12hModerateBSAVA Small Animal Formulary, 10th Ed
Cat (Domestic)PO2.5–5 mg/kgq12hExtrapolatedBSAVA Small Animal Formulary, 10th Ed

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