Question 1

What is Prazosin used for?

Accepted Answer

Prazosin is indicated for: CHF afterload reduction, Urethral relaxation, Urethral spasm (post-obstruction).

Question 2

What routes can Prazosin be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Prazosin dosing data?

Accepted Answer

Prazosin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Prazosin a controlled substance?

Accepted Answer

Prazosin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Prazosin?

Accepted Answer

First-dose syncope (start low). Used for urethral relaxation, systemic hypertension, and heart failure afterload reduction. Reflex tachycardia possible.

Question 6

What are the side effects of Prazosin?

Accepted Answer

First-dose syncope (start low). Used for urethral relaxation, systemic hypertension, and heart failure afterload reduction. Reflex tachycardia possible.

Question 7

How does Prazosin work?

Accepted Answer

Selective alpha-1 adrenergic blocker causing arterial and venous vasodilation. Also relaxes urethral smooth muscle and prostatic capsule.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.5–2 mg/kg	q8-12h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.25–0.5 mg/kg	q12-24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Prazosin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Prazosin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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