ExoticRx · exoticrx.com/drugs/nitroprusside
Nipride
Releases nitric oxide, activating guanylyl cyclase in vascular smooth muscle, causing vasodilation of both arteries and veins.
ICU drug — continuous IV infusion with arterial blood pressure monitoring required. Cyanide toxicity risk with prolonged use (>48h). Light-sensitive — wrap in foil. Immediate onset, very short duration.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Nitroprusside CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–5 mcg/kg/minCRI (continuous rate infusion) | Acute severe heart failure, hypertensive crisis | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Acute severe heart failure, hypertensive crisis
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–5 mcg/kg/min | CRI (continuous rate infusion) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.