Question 1

What is Nintedanib used for?

Accepted Answer

Nintedanib is indicated for: Idiopathic pulmonary fibrosis, Pulmonary fibrosis (investigational).

Question 2

What routes can Nintedanib be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Nintedanib dosing data?

Accepted Answer

Nintedanib dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Nintedanib a controlled substance?

Accepted Answer

Nintedanib is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Nintedanib?

Accepted Answer

Diarrhea most common side effect. Hepatotoxicity risk — monitor LFTs. Bleeding risk. Investigational for pulmonary fibrosis in dogs.

Question 6

What are the side effects of Nintedanib?

Accepted Answer

Diarrhea most common side effect. Hepatotoxicity risk — monitor LFTs. Bleeding risk. Investigational for pulmonary fibrosis in dogs.

Question 7

How does Nintedanib work?

Accepted Answer

Triple angiokinase inhibitor blocking VEGFR, FGFR, and PDGFR tyrosine kinases, reducing fibroblast migration, proliferation, and extracellular matrix deposition.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	2–5 mg/kg	q12h	Weak	Veterinary Pulmonology Literature Review
Cat (Domestic)	PO	2–4 mg/kg	q12h	Extrapolated	Veterinary Pulmonology Literature Review

Nintedanib

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Nintedanib dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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