ExoticRx · exoticrx.com/drugs/ketoconazole
Nizoral
Inhibits lanosterol 14-alpha-demethylase (CYP51), blocking ergosterol synthesis in fungal membranes. At high doses, inhibits adrenal and gonadal steroidogenesis.
Hepatotoxic — monitor liver enzymes. Strong CYP inhibitor (many drug interactions). Requires gastric acid for absorption (do not give with antacids). Also used for Cushing's disease (adrenal steroidogenesis inhibition).
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 3 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–10 mg/kg | q12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 5–10 mg/kg | q12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.