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Amphotericin B Liposomal

AmBisome

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antifungal

Routes

IV

Indications

Invasive fungal infectionsSystemic aspergillosis

Mechanism of Action

Liposomal encapsulation targets drug to fungal cells while reducing exposure to mammalian cell membranes. Binds ergosterol causing membrane disruption.

Side effects & warnings

Least nephrotoxic amphotericin B formulation. Still monitor renal function. Infusion reactions less common. Preferred formulation in veterinary practice.

Species with Amphotericin B Liposomal dosing data (3 dose rules)

Evidence levels across 3 dose rules

Strong×1Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published primary sources

  • · Carpenter's Exotic Animal Formulary, 6th Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 3 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 3 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV1–5 mg/kgq48h or 3x/weekStrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)IV1–3 mg/kgq48h or 3x/weekModeratePlumb's Veterinary Drug Handbook, 9th Ed

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