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Etodolac

EtoGesic, Lodine

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

NSAID

Routes

PO

Indications

Osteoarthritis pain and inflammationPain and inflammation

Mechanism of Action

Preferential COX-2 inhibitor that reduces prostaglandin synthesis, providing analgesic and anti-inflammatory effects with relatively less GI toxicity than non-selective NSAIDs.

Side effects & warnings

GI ulceration, renal toxicity, and hepatotoxicity possible. Monitor for melena, vomiting, and inappetence. Contraindicated with other NSAIDs or corticosteroids. Withdrawn from US veterinary market but still used internationally.

Species with Etodolac dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Strong×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO10–15 mg/kgq24hStrongPlumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database
Cat (Domestic)PO5–10 mg/kgq24hWeakPlumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database

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