ExoticRx · exoticrx.com/drugs/epoprostenol
Flolan, Veletri
Synthetic prostacyclin (PGI2) that causes potent pulmonary and systemic vasodilation and inhibits platelet aggregation via cAMP elevation.
Continuous IV infusion required — very short half-life (~6 min). Abrupt discontinuation can cause fatal rebound PH. Hypotension risk.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Epoprostenol CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–5 ng/kg/minContinuous IV infusion | Severe pulmonary hypertension | Weak | Veterinary Cardiology Literature Review |
| Cat (Domestic) | IV | 1–5 ng/kg/minContinuous IV infusion | Severe pulmonary hypertension (acute) | Extrapolated | Veterinary Cardiology Literature Review |
Severe pulmonary hypertension
Severe pulmonary hypertension (acute)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–5 ng/kg/min | Continuous IV infusion | Weak | Veterinary Cardiology Literature Review |
| Cat (Domestic) | IV | 1–5 ng/kg/min | Continuous IV infusion | Extrapolated | Veterinary Cardiology Literature Review |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.