Question 1

What is Digoxin used for?

Accepted Answer

Digoxin is indicated for: dilated cardiomyopathy, Supraventricular tachycardia.

Question 2

What routes can Digoxin be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Digoxin dosing data?

Accepted Answer

Digoxin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Digoxin a controlled substance?

Accepted Answer

Digoxin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Digoxin?

Accepted Answer

NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).

Question 6

What are the side effects of Digoxin?

Accepted Answer

NARROW therapeutic index. Monitor serum digoxin levels (target 1.0-2.0 ng/ml dogs). Toxicity: arrhythmias, anorexia, vomiting. Reduce dose in renal failure. Many drug interactions (quinidine, verapamil).

Question 7

How does Digoxin work?

Accepted Answer

Inhibits Na+/K+-ATPase, increasing intracellular calcium, enhancing contractility (positive inotrope). Also slows AV conduction (vagomimetic).

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.005–0.01 mg/kg	q12h	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.005–0.01 mg/kg	q48h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Digoxin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Digoxin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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