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Aglepristone

Alizin

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Reproductive

Routes

SC

Indications

Pregnancy termination/Closed pyometraPregnancy termination/Pyometra

Mechanism of Action

Competitive progesterone receptor antagonist with high affinity. Blocks progesterone action on the uterus, terminating pregnancy or treating pyometra.

Side effects & warnings

Pain at injection site. Not available in the US. Used for pregnancy termination and closed pyometra in Europe. Monitor for uterine discharge.

Species with Aglepristone dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Strong×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)SC10 mg/kgDays 1, 2, and 8 (or days 1 and 2 for mismating)StrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)SC10–15 mg/kgDays 1 and 2ModeratePlumb's Veterinary Drug Handbook, 9th Ed

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