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Tranexamic Acid

Cyklokapron, Lysteda

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Emergency

Routes

IVPO

Indications

coagulopathyHemorrhage

Mechanism of Action

Synthetic lysine analog that competitively inhibits plasminogen activation, preventing fibrin clot degradation. Stabilizes formed clots.

Side effects & warnings

Used for hemorrhage and coagulopathy. Thrombotic risk — avoid in DIC. Dose-dependent seizure risk (especially in renal disease). Slow IV injection.

Species with Tranexamic Acid dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Constant rate infusion (CRI)

Tranexamic Acid CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.

  • Dog (Domestic)IV
    10–25 mg/kgIV slowly, then CRI 10mg/kg/h

    Hemorrhage, coagulopathy

    ModeratePlumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV10–25 mg/kgIV slowly, then CRI 10mg/kg/hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)IV10–15 mg/kgIV slowlyWeakPlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Tranexamic Acid