Question 1

What is Sodium Thiosulfate used for?

Accepted Answer

Sodium Thiosulfate is indicated for: Cyanide poisoning.

Question 2

What routes can Sodium Thiosulfate be administered by?

Accepted Answer

Available routes: IV, PO.

Question 3

Which species have cited Sodium Thiosulfate dosing data?

Accepted Answer

Sodium Thiosulfate dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Sodium Thiosulfate a controlled substance?

Accepted Answer

Sodium Thiosulfate is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Sodium Thiosulfate?

Accepted Answer

IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.

Question 6

What are the side effects of Sodium Thiosulfate?

Accepted Answer

IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.

Question 7

How does Sodium Thiosulfate work?

Accepted Answer

Provides sulfur substrate for rhodanese enzyme to convert cyanide to thiocyanate, which is renally excreted. Also used topically for cisplatin extravasation.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	250–500 mg/kg	Single IV dose over 10-20 minutes	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	250–500 mg/kg	Single IV dose	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Sodium Thiosulfate

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Sodium Thiosulfate dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

Upgrade for Full Details