ExoticRx · exoticrx.com/drugs/atipamezole
Atipamezole
Antisedan
Drug Class
Routes
Indications
Mechanism of Action
Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
Side effects & warnings
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species with Atipamezole dosing data (8 dose rules)
Evidence levels across 8 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by 3 published primary sources
- · Carpenter 6e
- · Carpenter's Exotic Animal Formulary, 6th Ed
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (2 of 8 cited rules)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 8 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 0 mg/kg | Equal volume to medetomidine or 5x dexmedetomidine | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | IM | 0 mg/kg | Equal volume to medetomidine or 5x dexmedetomidine | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansArticles mentioning Atipamezole
- Rabbit Drug Dosing: A Vet's Quick ReferenceAntibiotic, analgesic, and antiparasitic dosing for domestic rabbits — and the oral antibiotics you must never reach for.
- Reptile Sedation: Why Temperature Is The Variable, Not The DrugMost failed reptile inductions, prolonged recoveries, and 'the snake just isn't going under' episodes trace back to one cause: the patient is too cold for the drug to do what it does in a mammal. Practical sedation protocols built around POTZ as the master variable.
- Bearded Dragon Drug Dosing: Vet Reference GuideAntibiotic, antiparasitic, and analgesic dosing notes for Pogona vitticeps — and what reptile physiology means for the drugs you reach for first.
More Antidote drugs
Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.