ExoticRx · exoticrx.com/drugs/sodium-polystyrene-sulfonate
Kayexalate, Kionex
Cation exchange resin that exchanges sodium for potassium in the GI tract, increasing fecal potassium excretion and lowering serum potassium.
Risk of sodium overload in cardiac patients. Intestinal necrosis reported with sorbitol. Monitor electrolytes closely. Constipation common.
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 500–1000 mg/kg | q8-12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | Rectal | 500–1000 mg/kg | q6-8h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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