ExoticRx · exoticrx.com/drugs/protamine
Protamine Sulfate
Strongly basic protein that forms stable complex with heparin (strongly acidic), neutralizing anticoagulant activity.
1mg protamine neutralizes ~100 units heparin. Slow IV administration. Hypotension, bradycardia, anaphylaxis risk (especially in patients with fish allergy or prior protamine exposure).
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1 mg/dose | IV slowly | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.