ExoticRx · exoticrx.com/drugs/pralidoxime
2-PAM, Protopam
Reactivates acetylcholinesterase by cleaving organophosphate from enzyme active site. Must be given before aging occurs (irreversible binding).
Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 20–50 mg/kg | IV slowly, repeat q8-12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.