ExoticRx · exoticrx.com/drugs/norepinephrine
Levophed
Potent alpha-1 and beta-1 adrenergic agonist with minimal beta-2 activity. Causes vasoconstriction (alpha-1) and increased cardiac contractility (beta-1).
First-line vasopressor for septic shock. IV CRI only. Tissue necrosis with extravasation — use central line if possible. Arrhythmogenic. Monitor blood pressure and perfusion parameters.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Norepinephrine CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.05–2 mcg/kg/minCRI | Refractory hypotension, septic shock | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | IV | 0.1–1 mcg/kg/minCRI | Septic shock (per RECOVER guidelines) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Refractory hypotension, septic shock
Septic shock (per RECOVER guidelines)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.05–2 mcg/kg/min | CRI | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | IV | 0.1–1 mcg/kg/min | CRI | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.