Question 1

What is Neostigmine used for?

Accepted Answer

Neostigmine is indicated for: Reversal of non-depolarizing neuromuscular blockade, Reversal of non-depolarizing NMB agents.

Question 2

What routes can Neostigmine be administered by?

Accepted Answer

Available routes: IV, IM, SC.

Question 3

Which species have cited Neostigmine dosing data?

Accepted Answer

Neostigmine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Neostigmine a controlled substance?

Accepted Answer

Neostigmine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Neostigmine?

Accepted Answer

Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.

Question 6

What are the side effects of Neostigmine?

Accepted Answer

Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.

Question 7

How does Neostigmine work?

Accepted Answer

Reversible acetylcholinesterase inhibitor that does not cross blood-brain barrier. Increases acetylcholine at neuromuscular junction for reversal of non-depolarizing NMB agents.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.02–0.04 mg/kg	Single IV dose with atropine/glycopyrrolate	Strong	Plumb's Veterinary Drug Handbook, 9th Ed; Veterinary Anesthesia & Analgesia, Lumb & Jones 5th Ed
Cat (Domestic)	IV	0.02–0.04 mg/kg	Single IV dose with glycopyrrolate	Moderate	Veterinary Anesthesia & Analgesia, Lumb & Jones 5th Ed

Neostigmine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Neostigmine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by 2 published primary sources

Sample dosing (2 of 2 cited rules)

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